ISCEP 2026 At Sunway Putra Hotel 17-18 August 2026
ABSTRACT
POSTER PRESENTATION ABSTRACT
P19
EFFICACY AND RESIDUAL ACTIVITY OF PYRIPROXYFEN AGAINST ANOPHELES CRACENS: IMPLICATIONS FOR ZOONOTIC MALARIA VECTOR CONTROL IN MALAYSIA
Intan Adibah SALIM, Nurul Nadiha MUHD TAMRIN, Rajiv RAVI, Olawale Quazim JUNAID*
Department of Parasitology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur Malaysia "[email protected]
ABSTRACT
Malaria remains a significant global health concern, with zoonotic malaria caused by Plasmodium knowles/increasingly reported in Malaysia. Conventional vector control strategies. such as long-lasting insecticide-treated nets (LLINS) and indoor residual spraying (IRS), have limited effectiveness against outdoor-biting Anopheles mosquitoes, necessitating alternative control approaches. This study evaluated the larvicidal efficacy of pyriproxyfen (PPF), an insect growth regulator, against laboratory-reared third-instar larvae of Anopheles craces, primary vector of P. knowlesi in Peninsular Malaysia. Laboratory bioassays were conducted to determine the concentrations required to achieve 50% and 90% adult emergence inhibition E and IE evaluate morphological alterations during larval and pupal development, and establish a diagnostic dosage. The study found that PPF effectively inhibited adult emergence, with IE and IE values of 0.0158 mg/L (95% CI 0.003-0.044 mg/L) and 3.35 mg/L [95% CI: 125-147 mg/L), respectively Distinct morphological abnormalities, including generalised dark pigmentation of larvae and pupae, red colouration in the early cephalic region, and abnormal cuticle deposition, were observed in An cracens. Based on probit analysis, the diagnostic dosage was determined and subsequently applied under simulated field conditions to assess the residual activity of PPF over time. Maximum residual larvicidal activity was sustained for up to four weeks under simulated field conditions. These findings indicate that PPF has strong potential as an effective larvicidal agent against An cracens and support its consideration in targeted vector control strategies to mitigate the rising burden of zoonotic malaria in Malaysia.
Keywords Anceles cracons, pyriprogfes, bioassey, vector centrol simulated field testing
INTERNATIONAL SCIENTIFIC CONFERENCE ON ENTOMOLOGY AND PEST SCEP) 2005